The Integrated Systems Group (ISG) was created by an influential group of digital and analogue VLSI pioneers in the early 1980s (John Mavor, Peter Denyer and Mervyn Jack). It has evolved into a group with strong analogue and digital VLSI interests alongside wider interests in novel computing paradigms, image processing and CMOS image sensing. The group's work ranges from "blue-sky" software and hardware activity to design research with a direct commercial focus, particularly in imaging (led by David Renshaw), programmable pulse-based signal processing chips (led by Alister Hamilton) and evolvable digital hardware for low-power processing (led by Tughrul Arslan). Alan Murray heads up the broad area of neural computing - with projects in analogue, pulse-based neural hardware, neural applications and neural-based sensor fusion using unsupervised training. Activity in the important area of System Level Integration (SLI) is led by Tughrul Arslan, although projects with an SLI component are undertaken by all members of the ISG. The research of this group has been supported continuously since 1981 from various sources including EPSRC, ESPRIT, Alvey and direct industrial funding and between four and five different integrated circuit designs have been fabricated successfully every year, leading to an annual output of between fifteen and twenty papers. In future, the group's work will move towards developing new architectures, algorithms and computational techniques for Systems on Chip implemented in Deep-Sub-Micron (transistors of dimensions <0.1micron) technology for applications in medical, signal processing and other domains. Most immediately, a new collaborative project recently funded by SHEFC will develop an ingestible chip, to perform diagnosis remotely and raising many major research questions with respect to power, sensor-fusion, integrated RF communications and lab-on-chip technology. The project is collaborative with the University of Glasgow, the Institute for System-Level Integration, medical, veterinary and environmental-modeling researchers. Looking further into the future, part of the ISG's work aims to connect live nerve cells to silicon substrates,.working with colleagues in the Silicon Technology Group and in Biomedical Sciences.